Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Preparation and evaluation of mebeverine hydrochloride as mucoadhesive buccal tablet for local anesthesia

Seham S Abdulhady¹ , Khaled M Hosny Ibrahim²

¹Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; ²Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

For correspondence:- Seham Abdulhady Email: Sehamhady@gmail.com Tel:+966551849789

Received: 6 January 2017 Accepted: 8 July 2017 Published: 31 August 2017

Citation: Abdulhady SS, Ibrahim KM. Preparation and evaluation of mebeverine hydrochloride as mucoadhesive buccal tablet for local anesthesia. Trop J Pharm Res 2017; 16(8):1805-1812 doi: 10.4314/tjpr.v16i8.8

© 2017 The authors.
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Abstract

Purpose: To formulate and evaluate an antispasmodic drug, mebeverine hydrochloride (Mbv-HCl), as a local anesthetic mucoadhesive buccal tablet.

Methods: Mbv-HCl loaded tablets were formulated, using a direct compression technique, with varying polymer concentrations including carbopol 934P alone, carbopol 934P/hydroxypropyl methylcellulose (HPMC) mixture, or carbopol 934P/chitosan mixture. The tablets were evaluated for physicochemical characteristics, in-vitro drug release, bioadhesive strength, swelling, ex-vivo residence time, ex-vivo permeation, drug permeation through the buccal membrane of sheep, and stability.

Results: The results indicate that formulation F4, which contains HPMC/carbopol 934P (3:1), showed the best in-vitro drug release profile. The release kinetics for all the formulations fitted well with Hixson-Crowell kinetic model. Bioadhesive strength, surface pH, and swelling index of F4 were 41.52, 6.36, and 231.2 %, respectively. Maximum residence time ex-vivo was exhibited by formulation F4, showing a maximum residence time of about 330 min with 80 % of Mbv-HCl permeated in 6 h ex-vivo. F4 was stable after storage for 60 days at 25 ^oC/60 % RH and 40 ^oC/75 % RH, with non-significant change (p < 0.05) in drug content, bioadhesive strength and in vitro release.

Conclusion: The optimized mucoadhesive buccal formulation is promising for delivery of Mbv-HCl, and displays high bioadhesion and adequate permeability through sheep buccal membrane to achieve a local anesthetic action.

Keywords: Mebeverine hydrochloride, Buccal, Mucoadhesive tablet, Swelling index, Bioadhesive strength, Local anesthetic